医療法人 修命会 土佐清水病院|癌|膠原病|アトピー|高知県土佐清水市

当院は自由診療となっております。
 

共同研究者の方々

 
 

以下にあげた論文はすべて、丹羽の指導の下、あるいは御自分で丹羽免疫研究所にこられ、 当研究所で実験をしたその成果にもとづいて書かれ、世界に発信されたものです。

各論文の第一著者や第二著者の方々は、その後日本各地の大学で 医学部教授などの要職を努めたり、医療の第一線で活躍されておられます。 丹羽免疫研究所から世界に向かって発せられたこれらの研究論文は、 こうした方々の例えば教授選考などにあたっても大きな業績として評価されています。

 

丹羽以外の方が丹羽とともに当研究所で研究され発信された論文リスト

丹羽以外の方が丹羽とともに当研究所で研究され発信された論文リスト
 
Effects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates.
Y. Miyachi, Y. Niwa
Br. J. Dermatol. 107:209-214, 1982
Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis.
Y. Miyachi, K. Yanase, S. Imamura, Y. Niwa
Arch. Dermatol. Res. 274:65-71, 1982
Effects of thalidomide on the generation of oxygen intermediates by zymosan-stimulated normal polymorphonuclear leukocytes.
Y. Miyachi, M. Ozaki, K. Uchida, Y. Niwa
Arch. Dermatol. Res. 274:363-367, 1982
Characterization of human peripheral blood T lymphocytes bearing receptors for autologous erythrocytes and T lymphocytes lacking these receptors.
T. Sakane, M. Honda, Y. Taniguchi, H. Kotani, Y. Niwa
J. Clin. Immunol. 2:20-29, 1982
Clofazimine suppresses polymorphonuclear leukocyte chemotaxis in vitro.
Y. Miyachi, M. Ozaki, Y. Niwa
Acta Dermatol. Kyoto 77:185-185, 1982
In vitro PUVA treatment does not affect superoxide generation by normal polymorphonuclear leukocytes.
Y. Miyachi, Y. Niwa
Acta Dermatol. Kyoto 77:301-302, 1982
Effects of psoriatic sera on the generation of oxygen intermediates by normal polymorphonuclear leukocytes.
Y. Miyachi, Y. Niwa
Arch. Dermatol. Res. 275:23-26, 1983
A case of psoriasis pustulosa. Treatment with potassium iodine and measurement of oxygen intermediates.
K. Nakajima, J. Komura, S. Nishijima, Y. Niwa
J. Kansai Med. Univ. 36(suppl):S-11-S-16, 1984
OKT4+ and OKT8+ lymphocytes produce soluble factors that can modulate growth and differentiation of human B cells.
T. Sakane, Y. Ueda, N. Suzuki, Y. Niwa, T. Hoshino, T. Tsunematsu
Clin. Exp. Immunol. 62:112-120, 1985
Auto-oxidative damage in cement dermatitis.
Y. Miyachi, K. Uchida, J. Komura, Y. Asada, Y. Niwa
Arch. Dermatol. Res. 277:288-292, 1985
Thalidomide and oxygen intermediates [letter].
Y. Miyachi, Y. Niwa
J. Am. Acad. Dermatol. 13:304-305, 1985
Anti-oxidant effects of retinoids on inflammatory skin diseases.
A. Yoshioka, Y. Miyachi, S. Imamura, Y. Niwa
Arch. Dermatol. Res. 278:177-183, 1986
Mechanisms of contact photosensitivity in mice. VI. Oxygen intermediates are involved in contact photosensitization but not in ordinary contact sensitization.
Y. Miyachi, S. Imamura, Y. Niwa, Y. Tokura, M. Takigawa
J. Invest. Dermatol. 86:26-28, 1986
Effect of antibiotics on the generation of reactive oxygen species.
Y. Miyachi, A. Yoshioka, S. Imamura, Y. Niwa
Erythema multiforme: A possible pathogenetic role of increased reactive oxygen species.
Y. Miyachi, S. Imamura, Y. Niwa
J. Clin. Lab. Immunol. 19:11-14, 1986
Prurigo pigmentosa: A possible mechanism of action of sulfonamides.
Y. Miyachi, A. Yoshioka, T. Horio, S. Imamura, Y. Niwa
Dermatologica 172:82-88, 1986
Anti-oxidant action of metronidazole: A possible mechanism of action in rosacea.
Y. Miyachi, S. Imamura, Y. Niwa
Br. J. Dermatol. 114:231-234, 1986
Antioxidant action of antimalarials.
Y. Miyachi, A. Yoshioka, S. Imamura, Y. Niwa
Ann. Rheum. Dis. 45:244-248, 1986
Analysis of interleukin-2 activity in patients with Beh?et's disease.
T. Sakane, N. Suzuki, Y. Ueda, S. Takada, Y. Murakawa, T. Hoshino, Y. Niwa, T. Tsunematsu
Arthritis Rheum. 29:371-378, 1986
Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis.
Y. Ozaki, T. Ohashi, Y. Niwa
Inflammation. 10:119-130, 1986
Evaluation of neutrophil acetyltransferase activity in patients with inflammatory disorders.
Y. Ozaki, T. Ohashi, Y. Niwa
Life Sci. 39:2343-2350, 1986
A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway.
Y. Ozaki, T. Ohashi, Y. Niwa
Biochem. Pharmacol. 35:3481-3488, 1986
Partial dependency of 1-oleoyl-2-acetyl-glycerol-induced superoxide production by human neutrophils on calcium ions and cytochalasin B.
Y. Ozaki, S. Kume, T. Ohashi, Y. Niwa
Biochem. Biophys. Res. Commun. 134:690-697, 1986
Effect of liposomal superoxide dismutase on human neutrophil activity.
K. Somiya, Y. Niwa, A.M. Michelson
Free Radic. Res. Commun. 1:329-337, 1986
Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: Evaluation of acetyltransferase activity.
Y. Ozaki, T. Ohashi, Y. Niwa
Acta Haematol. Jpn. 50:799-812, 1987
Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species.
Y. Miyachi, A. Yoshioka, S. Imamura, Y. Niwa
Gut 28:190-195, 1987
Nucleolus-associate J chains in myeloma cells: Clinical significance.
T. Kanoh, T. Ohnaka, T. Ohno, T. Takamatsu, N. Yasuda, H. Uchino, Y. Niwa
Eur. J. Haematol. 38:442-446, 1987
Nonsecretory IgD (kappa) multiple myeloma. Report of a case and review of the literature.
T. Kanoh, Y. Niwa
Am. J. Clin. Pathol. 88:516-519, 1987
Anti-oxidant effects of gold compounds.
Y. Miyachi, A. Yoshioka, S. Imamura, Y. Niwa
Br. J. Dermatol. 116:39-46, 1987
 
Decreased hydroxyl radical generation from polymorphonuclear leukocytes in the presence of D-penicillamine and thiopronine.
Y. Miyachi, A. Yoshioka, S. Imamura, Y. Niwa
J. Clin. Lab. Immunol. 22:81-84, 1987
Decreased skin superoxide dismutase activity by a single exposure of ultra-violet is reduced by liposomal superoxide dismutase pretreatment.
Y. Miyachi, S. Imamura, Y. Niwa
J. Invest. Dermatol. 89:111-112, 1987
SOD activity in skin of guinea pigs with experimental allergic or irritant contact dermatitis.
Y. Miyachi, S. Imamura, Y. Niwa
J. Clin. Biochem. Nutr. 3:113-116, 1987
Effect of liposomal encapsulated superoxide dismutase on patients with Kawasaki disease.
K. Somiya, Y. Niwa, S. Fukami, A.M. Michelson
Prog. Clin. Biol. Res. 250:573-575, 1987
The effect of the supernatants obtained from Sporothrix schenkii and Candida albicans culturi on the generation of reactive oxygen species by polymorphonuclear leukocytes.
A. Yoshioka, Y. Miyachi, S. Imamura, Y. Niwa
Mycopathologia 100:43-48, 1987
The effect of tranilast on the generation of reactive oxygen species.
Y. Miyachi, S. Imamura, Y. Niwa
J. Pharmacobiodyn 10:255-259, 1987
Effects of a novel synthetic vitamin A-like compound (a polyprenoic acid derivative, E-5166) on neutrophil derived reactive oxygen species.
Y. Miyachi, S. Imamura, Y. Niwa
J. Clin. Biochem. Nutr. 5:111-116, 1988
Reactive oxygen species in cutaneous inflammation.
A. Yoshioka, Y. Miyachi, S. Imamura, Y. Niwa
Acta Dermatol (Kyoto) 83:401-412, 1988
Role of reactive oxygen species in Arthus reaction.
A. Yoshioka, Y. Miyachi, S. Imamura, Y. Niwa
J. Clin. Biochem. Nutr. 5:215-220, 1988
Effect of sera from patients with obstructive jaundice on the generation of oxygen intermediates by normal polymorphonuclear leukocytes.
G. Ohshio, Y. Miyachi, H. Kudo, Y. Niwa, T. Manabe, T. Tobe
Liver 8:366-371, 1988
Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function.
Y. Ozaki, T. Ohashi, Y. Niwa, S. Kume
Inflammation 12:297-309, 1988
Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. Synovial fluid scavenging effect is enhanced in rheumatois arthritis patients.
H. Sato, T. Takahashi, H. Ide, T. Fukushima, M. Tabata, F. Sekine, K. Kobayashi, M. Negishi, Y. Niwa
Arthritis Rheum. 31:63-71, 1988
Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice.
S. Kawai, J. Komura, Y. Asada, Y. Niwa
Arch. Dermatol. Res. 280:171-175, 1988
Follow-up study of lipid peroxides, superoxide dismutase and glutathione peroxidase in the synovial membrane, serum and liver of young and old mice with collagen-induced arthritis.
T. Kasama, K. Kobayashi, F. Sekine, M. Negishi, H. Ide, T. Takahashi, Y. Niwa
Life Sci. 43:1887-1896, 1988
Cutaneous lesions in heavy-chain disease.
T. Kanoh, M. Takigawa, Y. Niwa
Arch. Dermatol. 124:1538-1540, 1988
Significance of reactive oxygen species in distal flap necrosis and its salvage with liposomal SOD.
S. Suzuki, Y. Miyachi, Y. Niwa, N. Isshiki
Br. J. Plastic Surgery 42:559-564, 1989
Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: The role of interleukin 1 and reactive oxygen species in inflamed sites.
T. Kasama, K. Kobayashi, T. Fukushima, M. Tabata, I. Ohno, M. Negishi, H. Ide, T. Takahashi, Y. Niwa
Clin. Immunol. Immunopathol. 53:439-448, 1989
Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice.
T. Kasama, K. Kobayashi, H. Kanemitsu, K. Nakatani, S. Kaga, N. Yamagata, M. Negishi, H. Ide, T. Takahashi, Y. Niwa
Immunol. Lett. 3:171-175, 1990
Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis.
H. Akamatsu, J. Komura, Y. Miyachi, Y. Asada, Y. Niwa
J. Invest. Dermatol. 95:271-274, 1990
The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: A possible mechanism of action of metronidazole in rosacea and acne.
H. Akamatsu, M. Oguchi, S. Nishijima, Y. Asada, M. Takahashi, T. Ushijima, Y. Niwa
Arch. Dermatol. Res. 282:449-454, 1990
Mechanism of anti-inflammatory action of glycyrrhizin: Effect on neutrophil functions including reactive oxygen species generation.
H. Akamatsu, J. Komura, Y. Asada, Y. Niwa
Planta Med. 57:119-121, 1991
Inhibitory effect of azelaic acid on neutrophil functions: A possible cause for its efficacy in treating pathogenetically unrelated diseases.
H. Akamatsu, J. Komura, Y. Asada, Y. Miyachi, Y. Niwa
Arch. Dermatol. Res. 283:162-166, 1991
Lipid peroxide and superoxide dismutase activity in trichophyte lesions.
O. Iizawa, T. Kato, H. Tagami, Y. Niwa
Arch. Dermatol. 127:1241-1243, 1991
Effects of subminimal inhibitory concentrations minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism.
H. Akamatsu, Y. Niwa, I. Kurokawa, R. Masuda, S. Nishijima, Y. Asada
Arch. Dermatol. Res. 283:524-528, 1991
Effects of cepharanthin on neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation.
H. Akamatsu, J. Komura, Y. Asada, Y. Niwa
J. Dermatol. 18:643-648, 1991
Effects of azelastine on neutrophil chemotaxis, phagocytosis and oxygen radical generation.
H. Akamatsu, Y. Miyachi, Y. Asada, Y. Niwa
Jpn. J. Pharmacol. 57:583-589, 1991
Antioxidant action of amlexanox.
H. Akamatsu, Y. Miyachi, Y. Asada, Y. Niwa
Jpn. Pharmacol. Therapeutics 19:2193-2198, 1991
Effect of doxycycline on the generation of reactive oxygen species: A possible mechanism of action of acne therapy with doxycycline.
H. Akamatsu, M. Asada, J. Komura, Y. Asada, Y. Niwa
Acta Dermatovenereologica 72:178-179, 1992
Effect of azelaic acid on neutrophil reactive oxygen species: Another possible mechanism of action in acne.
H. Akamatsu, Y. Miyachi, T. Horio, Y. Asada, H. Gollnick, Y. Niwa
Skin Research 12 (suppl 34):131-135, 1992
Changes in lipid peroxide levels and activity of reactive oxygen scavenging enzymes in skin, serum and liver following UVB irradiation in mice.
T. Hasegawa, F. Kaneko, Y. Niwa
Life Sci. 50:1893-1903, 1992
The effect of oxatomide on neutrophil oxygen radical generation.
H. Akamatsu, Y. Miyachi, Y. Asada, Y. Niwa
Biol. Pharm. Bull. 16:568-570, 1993
Long-term follow-up study of changes in lipid peroxide levels and the activity of superoxide dismutase, catalase and glutathione peroxidase in mouse skin after acute and chronic UV irradiation.
O. Iizawa, T. Kato, H. Tagami, H. Akamatsu, Y. Niwa
Arch. Dermatol. Res. 286:47-52, 1994
Inhibitory effect of gabexate mesilate on human neutrophil function.
K. Mikawa, H. Akamatsu, N. Maekawa, K. Nishina, H. Obara, Y. Niwa
J. Int. Med. Res. 22:245-254, 1994
Acceleration of phagocytosis in human neutrophils incubated with gabexate mesilate.
K. Mikawa, H. Akamatsu, N. Maekawa, K. Nishina, H. Obara, Y. Niwa
J. Int. Med. Res. 22:292-295, 1994
Inhibitory effect of prostaglandin E1 on human neutrophil function.
K. Mikawa, H. Akamatsu, N. Maekawa, K. Nishina, H. Obara, Y. Niwa
Prostaglandins Leukot. Essent. Fatty Acids 51:287-291, 1994
Changes in lipid peroxide levels and reactive oxygen species scavenging enzymes in skin lesions of inflammatory dermatological diseases.
O. Iizawa, H. Tagami, T. Kato, H. Akamatsu, Y. Niwa
J. Clin. Lab. Immunol. 43:69-78, 1994
Neutrophil chemotaxis, phagocytosis, and generation of reactive oxygen species show a hierarchy of responsiveness to increasing concentrations of N-formyl-Met-Leu-Phe.
O. Iizawa, H. Akamatsu, Y. Niwa
Biol. Signals 4:14-18, 1995
Effect of nadifloxacin on neutrophil functions.
H. Akamatsu, H. Sasaki, I. Kurokawa, S. Nishijima, Y. Asada, Y. Niwa
J. Int. Med. Res. 23:19-26, 1995
Enhanced effect of clarithromycin on neutrophil function in vitro.
H. Akamatsu, Y. Niwa, H. Sasaki, Y. Asada, T. Horio
J. Int. Med. Res. 24:185-189, 1996
Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro.
H. Akamatsu, Y. Niwa, H. Sasaki, Y. Matoba, Y. Asada, T. Horio
J. Int. Med. Res. 24:345-351, 1996
Inhibitory effect of local anaesthetics on reactive oxygen species production by human neutrophils.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, N. Maekawa, H. Obara, Y. Niwa
Acta Anaesthesiol. Scand. 41:524-528, 1997
Propofol inhibits human neutrophil functions.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, N. Maekawa, H. Obara, Y. Niwa
Anesth. Analg. 87:695-700, 1998
The effects of cimetidine, ranitidine, and famotidine on human neutrophil functions.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, N. Maekawa, H. Obara, Y. Niwa
Anesth. Analg. 89:218-224, 1999
The effects of sarpogrelate on superoxide production by human neutrophils.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, N. Maekawa, H. Obara, Y. Niwa
Reg. Anesth. Pain Med. 25: 181-186, 2000
The effect of phosphodiesterase III inhibitors on human neutrophil function.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, N. Maekawa, H. Obara, Y. Niwa
Crit. Care Med. 28: 1001-1005, 2000
Effects of pirenzepine, omeprazole, lansoprazole, and rabeprazole on human neutrophil functions.
K. Mikawa, H. Akamatsu, K. Nishina, Y. Niwa
Can. J. Anaesth. 48: 421-422, 2001
Effect of palmitic acid on neutrophil functions in vitro.
H. Akamatsu, Y. Niwa, K. Matsunaga
Int. J. Dermatol. 40: 640-643, 2001
 
 Effects of ondansetron, granisetron, ramosetron, and azasetron on human neutrophil functions.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, Y. Niwa
Gynecol. Obstet. Invest.53: 93-99, 2002
Effects of ropivacaine on human neutrophil function: comparison with bupivacaine and lidocaine.
K. Mikawa, H. Akamatsu, K. Nishina, M. Shiga, H. Obara, Y. Niwa
Eur. J Anaesthesiol. 20: 104-110, 2003
Effects of edaravone on human neutrophil function.
K. Mikawa, H. Akamatsu, K. Nishina, H. Obara, Y. Niwa
Acta Anaesthesiol. Scand. 49: 385-389, 2005
The effects of pentazocine, buprenorphine and butorphanol on human neutrophil functions.
K. Mikawa, H. Akamatsu, K. Nishina, T. Uesugi, Y. Niwa
Acta Anaesthesiol. Scand. 50: 643-644, 2006
Naloxone scavengers reactive oxygen species.
K. Mikawa, H. Akamatsu, K. Nishina, T. Uesugi, Y. Niwa
Acta Anaesthesiol. Scand. 50: 1171-1173, 2006
 

丹羽論文掲載雑誌インパクトファクター表

丹羽論文掲載雑誌インパクトファクター表
  筆頭著者分 合計 144.768
  筆頭著者以外の分 合計 184.071
  総計 328.839
   

註)インパクトファクターは2008年のものです。

註)現在不明のものは0としています。

註)当研究所名誉所長であり土佐清水病院長でもある丹羽の研究は、過疎地の一開業医として地域医療にも 取り組みつつ行われてきました。したがって掲載している丹羽論文は、 大学や公的研究施設で行われたものではなく、全てこの 土佐清水の丹羽免疫研究所で行われ、土佐清水の地から世界に向けて発信されてきたものです。

 
医療法人 修命会
土佐清水病院
〒787-0306
高知県土佐清水市幸町5-3
TEL:0880-82-2511
FAX:0880-82-4925

------------------------------
1.癌治療
2.膠原病治療
3.アトピー性皮膚炎治療
--------------------------
<<医療法人 修命会 土佐清水病院>> 〒787-0306 高知県土佐清水市幸町5-3 TEL:0880-82-2511 FAX:0880-82-4925